NeuroSAMe Plus contains 200mg of S-adenosylmethionine (SAMe) and vitamin cofactors to assist in the maintenance of healthy mood. SAMe, folinic acid (bioactivated vitamin B9) and vitamin B12 play a role in the synthesis of important neurotransmitters such as dopamine and serotonin. Vitamin B12 and folinic acid are also important cofactors for the synthesis of SAMe within the body.