Clinical Benefits

• Healthy ageing: As antioxidants, Polygonum cuspidatum and quercetin may support a healthy cardiovascular system, healthy immune function and normal blood sugar levels as a part of healthy ageing in healthy people.¹ Resveratrol has been shown in an animal study, to activate sirtuins which may assist in healthy ageing by leading to an overall increased defence status and enhanced neuronal cell survival.³ Quercetin is a potent inhibitor of sulphotransferase activity, inhibiting resveratrol sulphation in the liver and duodenum.⁴ The inhibition of resveratrol sulphation may increase its bioavailability.⁵
• A randomised, placebo controlled trial investigated the effect of Polygonum cuspidatum extract containing resveratrol on oxidative stress. Resveratrol induced a significant reduction in reactive oxygen species generation, via antioxidant effects. By reducing reactive oxygen species, Polygonum cuspidatum may help protect cellular DNA against free radical damage.⁶