SleepX supports healthy sleeping patterns and regulate healthy circadian rhythms. The restoration of the circadian rhythm relies on an adequate ebb and flow of serum cortisol and melatonin levels.¹² Elevated cortisol levels, a consequence of hypothalamic-pituitary-adrenal (HPA) overactivity, may affect sleep onset due to its melatonin-suppressing ability, resulting in hyperarousal. Magnesium regulates key circadian rhythm markers, aiding the reduction of serum cortisol and inducing serum melatonin.¹³Sensoril™ Ashwagandha has been shown to reduce cortisol, to help counteract HPA overactivity that disrupts melatonin production.¹⁴ Ornithine improves objective and subjective sleep and stress markers in healthy adults through the regulation of cortisol and DHEA-S production.

Digital devices and blue light exposure. Exposure to artificial nocturnal light (i.e. from electronic devices) interferes with the natural circadian rhythm cycle through the stunting of melatonin production in the hypothalamic suprachiasmatic nuclei.^15,16 Lutein and Zeaxanthin act as blue light filters, increasing macular pigment optical density, improving visual function and sleep quality due to preferential absorption of blue light.¹⁷ Daily supplementation of 20 mg of Lutein and 4 mg of Zeaxanthin has been clinically demonstrated to show significant improvements in sleep parameters including reducing sleep latency and increasing overall sleep duration and quality.¹⁸

SleepX supports restorative sleep (Figure 1). Typical sleep architecture consists of 80 to 120 minute sleep cycles which incorporate various stages and include rapid eye movement (REM) and non-REM sleep. The last stage of non-REM sleep is also known as slow wave sleep (SWS) which plays an important role in cerebral restoration and recovery.¹⁹ This natural sleep homeostasis is reset and supported through several phytonutrients, such as Lutein, Zeaxanthin and Sensoril™ Ashwagandha which decrease the time to the onset of slow wave sleep. Ornithine, magnesium and Triethylene glycol (TEG) contained in Ashwagandha leaves help to increase the time in non-REM/slow wave sleep during the cycle.^20,21,22 Combined, these actions support an increase in sleep quality for a more restorative and refreshing night’s sleep.

SleepX supports muscle relaxation and neuromuscular function. The proper relaxation of muscles is important to sleep and is facilitated by effective neuromuscular signalling.²³ Symptoms of magnesium deficiency include muscle cramps and spasms.²⁴