Clinical Benefits

Reduce toxic load by supporting gut barrier function, microbiome health and lipopolysaccharide (LPS) reactions. Glutamine may help to protect gut integrity and permeability¹ with zinc to reduce mucosal permeability,² and gram negative bacterial translocation.³ Taurine and the Traditional Chinese Medicine herb, gardenia, support the liver, with in vitro work showing taurine to reduce LPS activation of liver Kupffer cells.⁴ Arabinogalactans from larch provide prebiotic benefits to stimulate short chain fatty acid production, and lactobacilli and bifidobacterium growth as part of a healthy gut microbiome.^5,6

Improves cellular liver detoxification capacity: Milk thistle has been used in Western herbal medicine to assist the detoxification capacity of the liver. Silymarin inhibits ß-glucuronidase activity to assist the elimination of metabolites conjugated through phase II detoxification.⁷ Green tea polyphenols also stimulate the activity of hepatic detoxification enzymes, thereby promoting detoxification of xenobiotic compounds.⁸

Neutralises reactive toxins: Antioxidants, such as selenium, zinc and green tea, help protect against potential free radical damage from reactive toxins formed during phase 1.9 Cysteine and glutamine help synthesise glutathione,¹⁰ a major endogenous antioxidant, to help protect cells against reactive hydroxyl free radicals.¹¹ Glutathione is also a substrate for the major phase II detoxification pathway, glutathionation.¹² Pea protein is a natural source of glutamine and glycine. Green tea has also demonstrated high antioxidant activity with an ability to scavenge hydroxyl and superoxide radicals.¹³ It is hypothesised that green tea catechins, by decreasing the oxidative stress in cells, modulate the expression of antioxidant enzyme (AE) genes.¹⁴

Eliminates and conjugates toxins: The low reactive, non GMO high quality pea protein in Thermophase Detox Essentials supplies essential amino acids and nutrients to support major phase II conjugation pathways (Figure 1). Phase II detoxification pathways are dependent upon adequate substrates to carry out conjugation reactions.15 Phase II detoxification pathways transform intermediate metabolites formed from phase I detoxification to be more water-soluble and therefore more easily excreted in the bile and urine.¹⁶ Thermophase Detox Essentials with taurine,¹⁷ and the TCM herb, gardenia,¹⁸ assists in promoting the body’s elimination of wastes via the liver and bile.