Clinical Benefits

• For symptomatic relief of allergies and hay fever: A multicentre clinical trial involving 545 patients concluded that NRA2™ significantly reduced major symptoms of seasonal and perennial allergic rhinitis including sneezing, rhinorrhoea and nasal congestion.² Furthermore, absolute eosinophil count, mucociliary clearance time, peak expiratory flow rate and peak nasal flow rate also improved.³ In another trial, patients also reported a 70% improvement on quality of life parameters after 3 months.⁴ NRA2™ can be used alongside allergy medication without any additional adverse side effects.⁵
• Modulates histamine release and inflammation associated with allergic reactions: Alergeze contains a potent combination of ingredients that exhibit antihistamine, antioxidant and anti-inflammatory activity (Figure 1).⁶ NRA2™⁷ and Quercetin assist with mast cell stabilisation to inhibit histamine release and down regulate the production of allergic cytokines, inflammatory leukotrienes and prostaglandins.8 Bromelains induces proteolytic activity during inflammation⁹ and is an effective mucolytic agent.¹⁰
• Immune modulation: Quercetin may assist with immune tolerance by improving T helper 1 (Th1) and T helper 2 (Th2) balance.¹¹ Allergic sensitisation involves Th2 like adaptive immunity and production of antibodies.¹²