Clinical Benefits

• Hydroxyapatite contains naturally occurring bone growth factors and trace minerals to improve bone formation and density ⁵ (Figure One): Multiple studies on post-menopausal women have shown supplementation with calcium hydroxyapatite to maintain bone mass and significantly increase bone mineral density (Figure Two).^{5, 2} Hydroxyapatite calcium has shown superior performance in maintaining bone density over other forms of calcium including calcium carbonate.⁵ Its clinical success may be associated with the wide range of natural elements present, including transforming growth factor β (TGFβ) and insulin like growth factor 1 (IGF 1) which act locally to affect osteoblast proliferation and differentiation.⁷

• A meta-analysis of 10 randomised, controlled clinical trials on 608 subjects found that soy isoflavones significantly increase spine bone mineral density.⁶ The meta-analysis showed a significant 20.6 mg/cm² increase in spine bone mineral density in subjects consuming soy isoflavones, when compared with those who did not.⁶ Further improvements were found in subjects after 6 months consuming the soy isoflavones with an average 28.5 mg/cm² increase.⁶