Clinical Benefits

• Highly bioavailable calcium: Microcrystalline hydroxyapatite is a comprehensive whole bone concentrate consistently showing superior bioavailability over other forms of calcium.^1,4 It delivers highly absorbable forms of calcium, phosphorous and bioactive growth factors including transforming growth factor-b, insulin like growth factors, type 1 collagen, glycosaminoglycans and trace minerals to positively impact bone density.⁵
• Vitamin D for optimal calcium absorption: Vitamin D is involved in the efficiency of intestinal calcium absorption and also in the parathyroid hormone regulation of serum calcium levels. In a low vitamin D state, the intestine absorbs 10% to 15% of dietary calcium compared to 30% to 40% with adequate vitamin D levels.² Calcitite Protect contains 333 IU of vitamin D per tablet to assist calcium absorption and enhance skeletal strength.
• A meta-analysis of 12 randomised controlled trials has shown 700 IU to 800 IU of vitamin D to enhance skeletal strength. Vitamin D significantly reduced the risk of hip fracture by 26% and non-vertebral fracture by 23%.⁶ Vitamin D has also been shown to play a role in musculoskeletal function, with vitamin D receptors being identified in human muscle tissue. In a separate, double-blind RCT, 800 IU of vitamin D significantly improved musculoskeletal function, reducing the amount of falls in older patients by 49% over three months.⁷
• A two year study involving 60 postmenopausal women evaluated the efficacy of calcium hydroxyapatite (3.32 g/day) and calcium carbonate in the maintenance of optimal bone mineral density. Only calcium hydroxyapatite maintained bone mineral density, while calcium carbonate and the control group showed a significant reduction in bone mineral density.³ Similar results have also been demonstrated in a separate study of 40 postmenopausal women. Calcium hydroxyapatite significantly slowed the loss of trabecular bone in comparison to calcium carbonate over 20 months at a dose of 1.4 g calcium/day.¹