Clinical Benefits

• A meta-analysis of 17 randomised, controlled trials assessedthe effectiveness of EPA and DHA in relieving joint pain andinflammation:The results reported a significant reduction in jointpain intensity, joint swelling, morning stiffness and the number ofpainful and/or tender joints at a dose of 2.7 grams per day.¹ EPAand DHA exert anti-inflammatory and pain relieving actions via thefollowing mechanisms:
  - Suppression of COX-2 expression and the inflammatory cytokinesinterleukin (IL)-1 alpha and tumour necrosis factor (TNF)-alpha.⁵
  - Inhibition of Leukotriene B₄ (LTB₄) and reduced serum C-reactiveprotein levels shown in in vitro and clinical trials.^6,7,8
• 2.6 grams of EPA and DHA has been shown, in a randomised,placebo controlled study of 138 healthy males, to assist in themaintenance of triglycerides within the normal range.The studyreported a significant difference in triglyceride levels by 32% in thegroup taking 2.6 g of EPA and DHA. The study indicated that there wasa direct correlation between increased dosage and improved results.²
• A randomised, double blind, placebo controlled trial measuredthe mood and cognitive effects of fish oil: After 35 days, 2.4grams of EPA and DHA was associated with an improvement in brainfunctions associated with attention, particularly those involving thecortical processing. There was also a significant improvement inmood states including anger, anxiety, fatigue and confusion.⁴
• High quality, purified fish oil: Metagenics Fish Oils are sourcedfrom small, cold water fish using eco-fishing practices. The fish oilis molecularly distilled to ensure purity, stability and compliance withlow levels of contaminants. In accordance with our leading stance onquality and purity, we have ensured that the fish oil concentrates arewell below the Australian allowable levels of heavy metals, pesticidesand solvents.