Clinical Benefits

• NeuroCalm Sleep has sedative qualities which relieve insomnia and mild anxiety. California poppy has traditionally been used for its sedating effects, therefore contributing to a calm and restful sleep.⁶ Animal studies have suggested this sedative effect may be due to its ability to bind to GABA receptors and activate them.⁶ Lavender oil also acts via GABA receptors and provides additional calming effects by moderating production of stress hormones such as adrenocorticotropic hormone (ACTH), which stimulates cortisol production.^7,8 Passion flower has an anxiolytic effect by affecting GABA neurotransmitter pathways.⁹ Flavonoids from passion flower bind to the stress receptor sites of the GABA_A receptor.¹⁰ Zizyphus’ calming effects come from its ability to increase the effect of GABA.¹¹ GABA is a calming neurotransmitter and its activity promotes sleepiness and relaxation.¹²
• NeuroCalm Sleep reduces effects of excitatory neurotransmitters. Linalool from lavender oil inhibits acetylcholine release and glutamate binding in the cerebral cortex.¹³ Its ability to ease tension and promote a restful sleep come from this ability to alter excitatory neurotransmitters such as glutamate and noradrenaline.¹⁴ Zizyphus also reduces the neuroexcitatory effects of glutamate thus reducing wakefulness and alertness.^15,16