Clinical Benefits

• Relieves nervous unrest: Thyrocalm contains Rehmannia glutinosa and Melissa officinalis for the relief of irritability and nervous unrest.^10,11 In an animal study, Rehmannia glutinosa has been shown to lower adrenergic receptor affinity and peripheral conversion of T4 to T3.⁸ An in vitro study has shown Melissa officinalis to inhibit conversion of T4 to T3 and disrupt TSH binding to its receptor.⁷
• Calming: Rehmannia glutinosa is traditionally used in Chinese medicine as a yin tonic to improve symptoms of heart fire including insomnia and irritability.¹¹ In animal studies, Rehmannia glutinosa has reversed morphological changes to the pituitary and adrenal cortex by antagonising the suppressive effect of glucocorticoids on the hypothalamus-pituitary-adrenal axis.¹² The carminative and sedative actions of Melissa officinalis assist those with nervousness and sleeping problems.¹³ The possible anxiolytic activity of lemon balm results from an elevation of GABA levels that occurs due to inhibition of GABA-transaminase.¹⁴